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(More customer reviews)A great product, but don't use this as a daily Vitamin D3 supplement.
This high-dose Vitamin D3 pill is a specialized product used to quickly raise the blood levels of Vitamin D3 in an individual who is severely Vitamin D3 deficient. This dosage of Vitamin D3 (cholecalciferol) is used primarily for Stoss Therapy. The usual dose is one 50,000 iu pill once a week for six to eight weeks. This dosage should normally be used in conjunction with a blood test to establish serum levels of 15 hydroxyvitamin D (25(OH)D) before and after administration of six to eight weeks of once-weekly doses.
Although warnings about the toxic effects of Vitamin D3 have been exaggerated, a daily dose of 50,000 iu Vitamin D3 taken long-term has been shown to frequently induce spillage of calcium into the urine, and, in some individuals, kidney stones. The FDA says the high safe dose of Vitamin D3 is 2000 iu, which is very conservative. Based on recent research, several journal articles argue for daily doses ranging from 2,000 to 5,000 iu daily. None recommend 50,000 iu daily.
Supplementation is very appropriate if you are dark-skinned, older, do not expose skin to midday sun, or, if you regularly wear sunblock products. Vitamin D3 has been shown to reduce the incidence of cancer, many auto-immune diseases, and, inflammatory and infectious processes. Vitamin D3 is also protective of bone and muscle.
Again, the 50,000 iu dose is used in Stoss therapy. Don't use this product on a daily basis.
The optimal daily dose ranges from 2,000 to 5,000 iu of Vitamin D3. 2,000 iu is most appropriate for young and middle-age adults who are light-skinned and receive some Vitamin D3 from sun. 5,000 iu is most appropriate for older adults who absorb less Vitamin D3 from the gut and dark-skinned adults who do not create as much Vitamin D3 when they are exposed to sunlight. Biotech Labs also markets a 5,000 iu pill. Again, the FDA says 2,000 iu is the high safe dose for Vitamin D3.
You can also request a routine 25 hydroxyvitamin D test from your physician to establish your own Vitamin D3 blood level. 50 nanomoles/microliter are thought by current researchers to be adequate; 80 nanomoles/microliter are thought to be optimal. The majority of Americans are Vitamin D3 deficient.
The Vitamin D Council (vitamindcouncil.com)written primarily by Dr. John Cannell, MD is a good place to start your research.
Technical:
Several Vitamin D3 researchers are currently arguing for a daily dose of 2,000 to 5,000 iu to achieve an optimal Vitamin D3 serum (blood) level of 70 to 80 nanomoles per liter.
Here's a representative quote from one researcher:
"Generally, blood levels of 25-hydroxyvitamin D (25(OH)D), the non-active 'storage' form, of 50 nanomoles per litre (nmol/L) are suggested as the lower limit of the normal range. Studies have reported however that levels of parathyroid hormone (PTH), a hormone that regulates calcium balance, and calcium absorption are not optimised below serum 25(OH)D levels of 80 nanomoles per litre."
The researcher, Sonia Talwar, reported that the a dose of 800 iu raised 25(OH)D levels from a baseline average of 47 nmol/L to 71.4 nmol/L after three months. After additional three months at a higher dose (2,000 IU), the average serum concentration of 25(OH)D was 87 nmol/L."
Cited from:
"Dose response to vitamin D supplementation among postmenopausal African American Women." American Journal of Clinical Nutrition; Sonia A Talwar, et al., Bone Mineral Research Center, Winthrop University Hospital, Mineola, NY
I should note that I am not a researcher or a medical professional.
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